Amniotic and chorionic products have been used successfully for over a century in the setting of problematic tissue healing and have enjoyed a stellar safety record. Following recent clinical success with treating orthopedic injuries, there has been renewed interest in the use of allograft tissue treatments for musculoskeletal disease and injury. An abundance of scientific and clinical evidence has demonstrated the relationship between the molecular healing mechanisms and the clinical success of treatment in the setting of chronic inflammation where amnionic/chorionic products have been used.

Scientific investigations have concluded that there may be a significant clinical role for amniotic fluid in the setting of osteoarthritis pain. A study presented in 2015 at the American Academy of Pain Medicine Meeting concluded that “Amniotic fluid may be a safe and effective alternative to hyaluronic acid (HA) for osteoarthritis pain.”

“Amnionic fluid demonstrated in this study to offer pain and functional improvement that is greater at 13 weeks than at 30 days; thus it appears to offer longer-lasting relief at a higher level [than hyaluronic acid],” said lead author Didier Demesmin, M.D., a pain management specialist with the University Pain Medicine Center in Somerset, N.J.“It also demonstrated a much lower incidence of pain, swelling or inflammation compared to other injections,” said Noreen Rana, M.P.H., research director at the center.”